High-CBD strains tend to deliver very clear-headed, functional effects without the euphoric high associated with high-THC strains. They’re typically preferred by consumers who are extremely sensitive to the side effects of THC (e.g., anxiety, paranoia, dizziness).
With the passing of the Farm Bill in December 2018, industrial hemp became a legal agricultural commodity in all 50 states. While the DEA still considers CBD to be a Schedule I controlled substance, it clarified in a memo that trace amounts of CBD found in hemp stalks or seeds were legal.
Cannabis strains that have a high CBD:THC ratio are legal only in states with legal, regulated cannabis markets.
What are the medicinal effects of CBD?
Keep in mind that CBD levels may vary from crop to crop—even from plant to plant. We also recommend checking with dispensaries about the specifics of their strains’ CBD levels. It’s always a good idea to purchase only lab-tested products that clearly state the CBD/THC levels so you know what kind of experience to expect.
CBD has no lethal dose or known serious side effects. The idea of using cannabis-derived compounds for pediatric conditions remains a touchy subject in a culture where cannabis has been stigmatized.
Although THC is best known for its mind-altering euphoria, it too has important medical benefits. There’s some overlap in what CBD and THC can treat, but THC is particularly effective in relieving nausea, appetite loss, insomnia, among other symptoms. Many patients find that a balance of CBD and THC offers the best symptom relief as the two work together synergistically.
Cannabis consumers have long prized potency (a high THC content) as one of the main factors that makes a particular strain more desirable. Though traditional demand for THC has caused an oversaturation of high-potency products, many consumers are starting to prefer less intense products that are lower in THC and higher in the non-intoxicating compound called CBD (cannabidiol).
Existing evidence suggests that CBD could help treat some anxiety disorders. For instance, at doses of 400 to 600 milligrams, CBD can alleviate situational anxiety, such as public speaking . Interestingly, cannabis cultivars that are high in CBD and low in THC may be better than other cultivars for alleviating depression .
CBD’s actions within the brain and body are quite complicated. It’s very likely that the beneficial effects of CBD operate through diverse biological pathways, rather than by a single action. More research is needed to fully understand the mechanisms by which CBD relieves ailments such as seizures .
The scientists behind this study noticed that researchers had been utilizing pure, single-molecule CBD, which resulted in a bell-shaped dose-response curve. This curve indicates that CBD’s efficacy plummets at very high and very low doses.
Epilepsy and seizures
CBD fits the definition of a psychoactive substance as it can subtly alter perception and mood. However, it’s important to reiterate that unlike weed, CBD does not cause intoxication. CBD is a non-intoxicating substance, so it cannot stimulate the level of sensory and psychological effects that THC does.
In 2015, researchers from the University of Montreal conducted a comprehensive review of CBD as an intervention for addictive behaviors. They concluded that CBD might have a beneficial impact on opioid, cocaine, and psychostimulant addiction. In addition, studies suggest that CBD may also be helpful in the treatment of tobacco addiction . One reason may be CBD’s potential ability to ease the anxiety that leads people to crave drugs such as heroin .
The Hebrew University of Israel published a study in 2015 that documented the potency of single-molecule CBD extract versus the potency of whole-plant CBD-rich extract. It found that extract taken from whole plant CBD-rich cannabis seemed to be therapeutically superior to single-molecule extract.
The phytocannabinoid cannabidiol is a non-intoxicating molecule that results from the heating, or decarboxylation , of cannabidiolic acid (CBDA). Most cannabis cultivars have lower concentrations of CBD than THC. However, following an explosive discovery in 2009 , droves of CBD-rich cultivars began cropping up across the US.
Some research suggests that CBD may reduce anxiety and self-deprecating thoughts, and there’s evidence that CBD has antipsychotic effects in people with schizophrenia. But other studies show no significant benefit of CBD over a placebo.
Every variety of the cannabis family produces cannabinoids, including hemp. While CBD and THC are the most well-known cannabinoids, there are many different types, and only recently have significant resources been poured into their study. Our brains have specific receptors designed to accept cannabinoids, known as CB1 and CB2. These receptors are responsible for the assimilation of cannabinoid molecules into your system, resulting in the psychoactive and immune responses correlated with cannabis consumption.
A 2017 clinical trial published in The New England Journal of Medicine found that CBD was highly effective in reducing seizures in people with Dravet syndrome, a rare form of epilepsy. The FDA subsequently approved an oral CBD solution, called Epidiolex, for treating the rare disease.
Research on CBD
According to nonscientific anecdotal evidence, CBD is good for treating discomfort and illness of all kinds. Sufferers of everything from anxiety and aches to epilepsy and cancer are evangelizing for the CBD molecule. But the largely prohibited status of cannabis has prevented many long-term, academically rigorous studies on most cannabinoids in isolation, leaving these anecdotal claims mostly uninvestigated until recently.
Within the CMCR, there is also “much interest in the possible anti-inflammatory effects of CBD, for use in arthritis of various types, including knees and hands,” Atkinson said. Recent in vitro research with human cell lines afflicted with rheumatoid arthritis has suggested that CBD treatment may help reduce inflammation.
However, now that cannabis is enjoying a research renaissance by way of legalization efforts, medical science is gaining a much more detailed perspective on this popular and fascinating plant. According to
CBD, short for cannabidiol, is a trending ingredient the natural products industry and is the focus of a new area of cannabis research. CBD is one of many cannabinoids, or molecules produced uniquely by the cannabis family. Unlike tetrahydrocannabinol (THC, the primary psychoactive element in marijuana), CBD is non-psychoactive, meaning it doesn’t have a strong effect on cognitive brain activity and doesn’t cause the “high” associated with marijuana.