In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.
While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term known as the entourage effect. This effect of THC and CBD working together is well-known, but whether other cannabinoids have entourage effects is not well understood.
A recent study in which tumor growth was initiated in mice (two-stage mouse skin carcinogenesis model) showed cannabinoids might be effective in inhibiting both inflammation and tumor growth. Since anandamide has been shown to fight breast cancer in vitro and in vivo, this shows promise that CBC and other cannabinoids might one day be a chemopreventive agent.
The specific plant enzymes cascade and “direct” the breakdown product into one of the three lines. For CBC, it converts from CBGA into cannabichrome carboxylic acid (CBCA), and then finally to CBC after exposure to heat or ultraviolet light.
CBC as a potential cancer fighter was first published in a 2006 study that looked at cannabinoids other than THC and their possible effects on cancer. While THC is known for its anti-tumor properties for several different forms of cancer, its powerful psychotropic qualities can make it difficult for chemotherapy use. So far, research has found CBC to be the second-most-potent cannabinoid at inhibiting the growth of new cancer cells (CBG was the most potent).
Cannabichromene may be a powerful cancer fighter, and the reason might be its interaction with the body’s natural endocannabinoid, anandamide. CBC also appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream.
In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis. The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteract many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.
Much of the research to date has suggested that due to the entourage effect, CBC is most effective when taken in conjunction with other cannabinoids (which is why we suggest giving full-spectrum CBD oil a try).
CBC Heavy Sativas
Rather than interacting directly with endocannabinoid receptors, CBC boosts the beneficial effects of other cannabinoids by protecting CB1 and CB2 receptors from being degraded.
Here’s How to Enjoy the Benefits of CBC
Hemp and cannabis plants easily absorb anything present in the soil it is grown in. Nutrient-rich soil and optimal growing conditions will produce the highest quality plant. But if the plant is grown in soil containing pesticides, heavy metals or other contaminants, it will absorb those as well. And whatever the plant absorbs, will be extracted into the CBD oil that’s made from it and then passed directly to you. That’s why choosing naturally grown products is so important. Look for brands that clearly and specifically explain where and how their product was grown.
Of course, other cannabis compounds, like CBD and THC, are used to treat many of these same conditions.
CBC may be an effective alternative to the highly-addictive opioids and steroids that are routinely prescribed as pain management medication. This is a serious problem for athletes, many of whom have already turned to CBD to manage their pain.
Research indicates that CBC binds more effectively with the TRPV1 and the TRPA1 receptors, both linked to the perception of pain and acting as molecular integrators of physical and thermal stimuli.
In its natural form, cannabis does not produce active cannabinoids such as CBD or CBC. The plant itself produces many acidic cannabinoids that can only be transformed into their active state through a process known as decarboxylation. In simple terms, decarboxylation means exposing cannabis to high temperatures or UV rays so that all acidic cannabinoids are transformed into non-acidic active compounds.
– Neural regeneration
CBC can also play a fundamental role in the “entourage effect”, in which cannabinoids act synergistically to modulate the overall effect of cannabis. Thus, a study found that when used together, CBC and THC can control inflammation more effectively than when used separately.
For many years, it was thought that once you reach a certain age, the brain stops growing. But this is not true. For example, the cells responsible for learning and memory are continuously produced through a process known as neurogenesis. In people suffering from Alzheimer’s and dementia, this neurogenesis is disturbed.
Like the other cannabinoids, its effects are produced through interaction with the receptors of the endocannabinoid system of the human body. But unlike THC, CBC binds quite badly with the CB1 receptors in the brain, which is where THC exerts its psychoactive effects. In fact, CBC seems to interact on receptors other than the best-known CB1 and CB2 receptors.