CBD is one of the many chemical compounds that is found in the cannabis plant—referred to as cannabis sativa. There are two primary parts of the plant that humans use. One is THC, or Delta-9-Tetrahydrocannabinol, and the other is CBD. Though they’re from the same plant, THC and CBD are quite different from each other.
“Since discovering the endocannabinoid system (ECS) in the body in the 1990s, CBD has been researched more extensively. The ECS is a central regulatory system restoring normal balance and homeostasis in a range of human physiologic systems throughout the body and brain and has cannabinoid receptors and chemicals in its function,” explains Dr. Matharu-Daley.
It’s important to point out that CBD is not regulated by the FDA and therefore dosages might not be accurate. It’s also difficult to know what an appropriate dose is the first time you try a new product.
Can Interact With Other Medications
There are several reasons why someone might want to use CBD. The substance can be found in a multitude of products ranging from pain-relieving creams to edible tinctures to skincare. Research is still underway, but over the last few decades scientists have become more aware of how CBD might ibeneficial when applied either topically or ingested.
Also known as “cotton mouth,” CBD can potentially cause your mouth and eyes to feel very dry, notes Dr. Brent A. Bauer via Mayo Clinic. Though this side effect is more likely to occur with THC, it can happen with CBD, as well.
In some cases, those who ingest CBD supplements might experience nausea, says Dr. Matharu-Daley. This depends on how sensitive the person is to CBD, as well as the amount they ingest.
“CBD is not an intoxicating substance, whereas THC is a psychoactive that can get you high,” explains Dr. Jas Matharu-Daley, a physician and consultant for a brand that specializes in CBD production.
Here is just some of what the current evidence says.
Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.
Since some CBD oils contain trace amounts of THC, you should avoid driving or using heavy machinery when taking CBD oil, particularly when first starting treatment or using a new brand.
In an analysis of 14 published studies (nine involving animals and five involving humans), scientists with the University of Montreal concluded that CBD showed promise in treating people with opioid, cocaine, or psychostimulant addiction.
Proponents claim that CBD oil can treat a wide variety of health problems, including:
Patients should take particular care, however, if they have prior problematic substance use. High doses of medicinal cannabis, taken over long periods, may lead to dose escalation and misuse. The abrupt cessation (quitting) may then cause withdrawal symptoms, such as mild forms of restlessness, irritability, insomnia, vivid dreams, and decreased appetite.
Patients with a hereditary risk of psychosis or other psychiatric conditions (e.g. schizophrenia or depression), and patients with cardiac/coronary conditions should avoid the use of cannabis and cannabinoids, as they may potentiate these conditions.
Recent scientific studies into this matter suggest a small proportion of the population has genetic predispositions that increase the risk of developing chronic psychotic symptoms when using cannabis (as a medicine or otherwise).
Specifically, it is possible that a THC overdose will result in acute hypotension and/or tachycardia. In some cases, nausea and vomiting and diarrhea may be observed as well. That aside, impaired executive function and motor control may lead to feelings of confusion, depersonalisation, loss of control, or even helplessness. Also reddened eyes and a dry mouth may be experienced as very unpleasant to some individuals. Most adverse effects will spontaneously resolve, usually within a few hours, when serum levels of THC fall.
The consumption of medicinal cannabis has not been shown to lead to life threatening adverse events, even at very high doses. However, an overdose of cannabis (THC) can result in a range of adverse effects, with high variability in tolerance between subjects. The most common adverse effect of overdosing a single dose of THC is anxiety, which, in some cases, may lead to mild acute psychotic states (panic attacks). In addition, increased heart rate and changes in blood pressure may occur.
On rare occasions, cannabis use can induce a state of psychosis in individuals with a genetic predisposition. As a result, patients with a (family) history of psychotic disorders, particularly schizophrenia and bipolar disorder, should be under careful psychiatric monitoring when using medicinal cannabis. Moreover, a short, acute psychotic like episode (involving anxiety and catastrophic thinking) is possible in the case of non-predisposed individuals, especially when very high doses of THC is taken.
When cannabis of unknown, often illegal, origin is used, there is always a chance the product is contaminated with pesticides, growth enhancers, heavy metals or microbes. These contaminants are very damaging to the health of a patient. Bedrocan’s medicinal cannabis is quality controlled by an external, internationally certified laboratory. The results of the analysis of every batch are presented in a Certificate of Analysis (CoA). This level of quality assurance shows our products to be free of harmful contaminants. Moreover, using standardised medicinal cannabis products is critical to ensuring the same dose is taken each time. This reduces the risk of overdosing and consequently that of unwanted side effects.