Okay so this one might sound a little scary, but vape pens are easy to use and can go undetected because they produce little smoke. The plus side of taking CBD in a vape pen is that when CBD is inhaled, it enters the lungs where it rapidly passes into the bloodstream. However, it’s important to note that the long-term safety of vaping is still unknown.
It depends on a variety of factors, such as how strong the CBD oil is (the stronger the concentration, the faster you will feel its effects) as well as how you are consuming it. For example, if you are taking CBD oil by placing a few drops under your tongue, it should take effect in around 15 to 45 minutes , while a topical application may take longer.
3. In a smoothie
It can, but it probably won’t. While some people do feel that CBD oil makes them feel more alert, preliminary studies have shown that CBD oil is an effective way to treat insomnia.
Again, this is up to you and how CBD oil affects your body. People who find that CBD oil makes them feel energised, awake and clear-headed may prefer to take it in the mornings (or afternoons when they need a bit of a boost), while those who find that CBD oil helps them unwind and relax may prefer to take it in the evenings.
CBD oil also comes in a capsule form, which can be a good option for people who want to maintain a consistent amount of the compound in the body. However when CBD is ingested it passes through the digestive tract which means you might have to wait upwards of 30 minutes before experiencing any effect.
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.
Potential drug-drug interactions with CBD include:
In addition, the stroke volume (the amount of blood remaining in the heart after a heartbeat) was significantly reduced, meaning that the heart was pumping more efficiently.
CBD shows promise in the treatment of anxiety disorders, suggests a 2015 review of studies in the journal Neurotherapeutics. According to the investigators, CBD demonstrated potent anxiolytic (anxiety-relieving) effects in animal research, albeit with counterintuitive results.
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
On the way to the liver, cannabinoids will interact with receptors in the gut, so the effect on conditions like inflammatory bowel disease will be more pronounced. Once in the liver, three enzymes will start to modify THC and CBD in a process called “first-pass metabolism.” THC is largely converted to 11- OH – THC , which appears to cause a stronger high than THC . This, along with the long duration of edibles, is why new users should become comfortable with being high before using edibles containing more than 5 mg of THC .
Low doses of cannabinoids have not been shown to cause problematic interactions with other drugs. When people start using hundreds or thousands of milligrams of CBD , however, the body may struggle to break down the other pharmaceuticals a person is taking. But such high doses are not normally required for therapeutic benefit when using quality products. People with certain conditions or those who can only access CBD isolates may need to use large doses. Tell your doctor if you are taking high doses of CBD , so that she or he can help manage potential cannabinoid-drug interactions.
Oral-mucosal drugs are absorbed directly into the blood vessels in the mouth and under the tongue. If sprayed under the tongue, the patient should try to wait at least one minute before swallowing (see Accidental Ingestion below.) Effects usually start after 15-30 minutes and peak around an hour and a half after administration. For consistency, it is best to avoid eating immediately before or after using a tincture. 
Oral mucosal tinctures usually come in one of two forms: an under-the-tongue spray or a dropper with a marking at a specific volume (usually 0.5 ml or 1.0 ml). This allows for consistent, measurable dosing. Pay close attention to the labels on these products. Products should be labeled with the dose of cannabinoids per spray or per ml.
The longer-lasting effect of edibles and capsules make them suitable for many chronic conditions.