Our immune system alone has up to 350 different signalling elements which could potentially offer an explanation as to why there can be so many unintentional pharmaceutical drug interactions. When CBD is introduced to the overwhelmingly complex human physiology, in the context of our immune system, the effects of homeostasis can trickle down all of 350 different signalling elements.
In this article, we explore the physiological effects of CBD on the body. You shouldn’t think of CBD as being just another food supplement that supports overall wellbeing. We will be taking a look at the intense scientific research that is taking place across the globe on why CBD is important for human physiology. At Purity Hemp Company we are committed to delivering educational resources on CBD that are rooted in science and evidence-based research.
When you start to present the symptoms of having an imbalance in your body, you may seek the assistance of pharmaceutical drugs to help you to regain a sense of natural balance. However, it is important to remember that these pharmaceutical drugs only work at the level of the symptoms, not the systems, which could cause immense strain on your physiology. Pharmaceutical drugs are effective at putting out fires, but they can knock other areas of your body out of balance in the process.
Where Does CBD Work?
Rather than working at the level of the symptoms, CBD works at the epicentre of balance, our homeostatic system. In our central nervous system, there are cells that are covered with cannabinoid receptors. When CBD binds to these receptors, it has the ability to communicate with the cell and send a message through it, journeying down into the nucleus of the cell to ultimately reach our chromosomes.
Chromosomes carry genetic information about everything that our body does. Genes are the codes for every protein that we make in our body, which includes all of the signalling molecules that are in charge of our physiology. From the cytokines that run our immune system to the neurotransmitters that run our nervous system. Throughout our physiology, we have receptors that are specifically designed to bind with CBD.
CBD has been attracting widespread interest in the UK due to its natural therapeutic properties. In the space of only a few years, CBD products have been openly welcomed and embraced by wellness communities as a natural way for consumers to find a sense of blissful calm and overall wellbeing amidst the hustle and bustle of everyday life.
Every aspect of human physiology is based around the balance of ‘polar opposites’, resulting in homeostasis. In our physiology, if you look at the immune system, the opposites are anti-inflammation and inflammation. When there is an even balance between these two opposites, your immune system is functioning correctly. Many people believe that all inflammation is bad, but this isn’t the case. Your body needs a certain level of inflammation to protect itself from injury and infection.
Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London have conducted pioneering research into CBD and the neural correlates of anxiety. At high concentrations, CBD directly activates the 5- HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect. This G-coupled protein receptor is implicated in a range of biological and neurological processes, including (but not limited to) anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting.
CBD also exerts an anti-cancer effect by activating PPAR s on the surface of the cell’s nucleus.
Although CBD has little binding affinity for either of the two cannabinoid receptors ( CB1 and CB2 ), cannabidiol modulates several non-cannabinoid receptors and ion channels. CBD also acts through various receptor-independent pathways—for example, by delaying the “reuptake” of endogenous neurotransmitters (such as anandamide and adenosine) and by enhancing or inhibiting the binding action of certain G-protein coupled receptors.
Whereas cannabidiol directly activates the 5- HT1A serotonin receptor and several TRPV ion channels, some studies indicate that CBD functions as an antagonist that blocks, or deactivates, another G protein-coupled receptor known as GPR55 .
Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA -A receptor. In other words, CBD interacts with the GABA -A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid ( GABA ), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium and other Benzos are mediated by GABA receptor transmission. CBD reduces anxiety by changing the shape of the GABA -A receptor in a way that amplifies the natural calming effect of GABA .