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EPIDIOLEX is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex in patients 1 year of age and older.

Do not use Epidiolex for other reasons or if not prescribed by a licensed health care provider.

Epidiolex is Approved for Use:

Liver problems: Increases in liver function can be seen on blood tests in some people taking Epidiolex, especially people who may also be taking valproate (also called valproic acid or sodium valproate). It has also been seen in people taking clobazam with Epidiolex.

Using alcohol and other products that depress the central nervous system or brain activity (CNS depressants) while taking Epidiolex can increase sleepiness or sedation.

Some people taking Epidiolex and valproic acid or valproate (Depakene or Depakote) or clobazam (Onfi) have had an increase in liver enzymes.

Do not direct the medicine to the back of the mouth or throat. This may cause choking.

Table 4 lists the adverse reactions that were reported in at least 3% of EPIDIOLEX-treated patients, and at a rate greater than those on placebo, in the placebo-controlled trial in TSC.

The effectiveness of EPIDIOLEX for the treatment of seizures associated with TSC was demonstrated in a randomized, double-blind, placebo-controlled trial in 224 patients aged 1 to 65 years (Study 4; NCT02544763).

Drug Interaction Studies

Effect Of EPIDIOLEX On Caffeine

Adverse reactions were similar in pediatric and adult patients with TSC.

Tell your healthcare provider about any side effect that bothers you or that does not go away.

No effects on the exposures of cannabidiol or metabolite exposures were observed following administration of a single dose of EPIDIOLEX 200 mg in patients with mild (Child-Pugh A) hepatic impairment. Patients with moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment had an approximately 2.5 to 5.2-fold higher AUC, compared with healthy volunteers with normal hepatic function [see DOSAGE AND ADMINISTRATION, WARNINGS AND PRECAUTIONS, Use In Specific Populations].

What is the Most Important Information I Should Know About EPIDIOLEX (cannabidiol)?

EPIDIOLEX significantly reduced seizures in people living with LGS, Dravet syndrome, or TSC for whom multiple previous seizure medicines did not work well.

Families share everything. For many, that includes the fears and frustrations of living with seizures. But with seizure reduction from EPIDIOLEX, families can share something else. They can experience the relief of more moments like these and look forward to what may be next.

Support & Copay Program

What is EPIDIOLEX (cannabidiol)?

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If you are pregnant or plan to become pregnant, EPIDIOLEX may harm your unborn baby. You and your healthcare provider will have to decide if you should take EPIDIOLEX while you are pregnant.

EPIDIOLEX is a prescription medicine that is used to treat seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex in patients 1 year of age and older.