Soothing the tissues without triggering any sort of psychoactive response can be accomplished by using a compound with selective interaction with the CB2 receptor. Beta-caryophyllene (BCP) is a sesquiterpene compound found in hundreds of different plant species, and it has recently been recognized for its unique ability to interact with CB2 but not CB1 receptors. 3 Thus the alleged benefits of CBD or THC can be obtained without the psychoactive effects by using a product containing BCP. doTERRA’s new Copaiba essential oil has the highest BCP content of any oil, around 55% as confirmed by GC/MS analysis of doTERRA’s own Copaiba oil.
Research shows that CBD acts on the enzyme FAAH, which breaks down anandamide. CBD actually slows down the enzyme’s activity, which leads to increased levels of anandamide in the body. 1 The reason why this is significant is because anandamide interacts with CB1 and CB2 receptors. Higher levels of anandamide would result in increased feelings of euphoria due to increased activation of CB1 receptors, as well as soothing of the tissues due to activation of CB2.
A “runner’s high” is a perfect example of the EC system at work. After a long period of strenuous exercise, the body begins to produce anandamide in order to activate CRs and turn on the EC system. The “runner’s high” has two components: slight euphoria, and soothing of the discomfort in the muscles and joints. These two outcomes are linked with two distinct structures: the CB1 and CB2 receptors. CB1 receptors are mainly found in the brain and central nervous system, and are linked with pleasure and reward pathways. CB1 receptor activation leads to feelings of euphoria. CB2 receptors are found in the rest of the body, like the muscles, skin, and vital organs. They are mainly found on the surface of white blood cells, and their activation affects the regulation of inflammation chemicals called cytokines.
In this article, we review the endocannabinoid system and the effects of tetrahydrocannabinol (THC), Cannabidiol (CBD), and Beta-caryophyllene (BCP).
Cannabinoid receptors (CRs) not only detect the presence of ECs, but they are also affected by molecules from outside sources that chemically resemble endocannabinoids. The term cannabinoid refers to any compound, produced by the body or from an outside source, that triggers the EC system by activating CRs. Anandamide is an EC compound produced in the body. Anandamide activates two types of CRs, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).
The endocannabinoid system
The endocannabinoid (EC) system helps the body manage anxiety, inflammation, and other physiological responses to different forms of stress. During strenuous exercise, stress, and other related stimuli, the body produces compounds called endocannabinoids. Endocannabinoids (ECs) are signaling molecules that trigger the activation of the EC system when they are detected by cannabinoid receptors.
All Factors Considered
And that means that we have to have some opportunity for a daily use or some opportunity for consistent exposure. The cost difference between the two is substantial and what little we know now currently about dosage with CBD suggests that the cost for that would be in excess of well over one hundred dollars per day. That doesn’t make any sense. It’s not sustainable. And so what we really get is inconsistent product delivery with very small amounts, and we don’t get the efficacy.
Is CBD Legal?
Indirect Receptor Stimulation
The 2018 Act did not remove the FDA’s “authority to regulate products containing cannabis or cannabis-derived compounds under the FD&C Act and . . . the Public Health Service Act (PHS Act).” 15 This means that any product containing cannabis or cannabis compounds, such as CBD, is still subject to the same laws as any other drug or dietary supplement. This includes CBD oil. Any product containing CBD, regardless of its THC content, cannot currently be sold as a dietary supplement. 16 This is because the FDA has approved neither THC nor CBD under the FD&C Act. 17
The Drug Enforcement Administration (DEA) is responsible for enforcing the Controlled Substances Act. They also regulate “the handling of all controlled substances, including those being used by researchers to conduct studies.” 9
Without FDA oversight of CBD, it is difficult to be certain of both the amount and purity of CBD a product may contain. Regardless of what a product may claim, it may contain no CBD at all, while others may vary in purity or consistency of formula. “Over the past several years, FDA has issued several warning letters to firms that market unapproved new drugs that allegedly contain cannabidiol (CBD). As part of these actions, FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to contain.” 21
Why Isn’t doTERRA Producing a CBD Oil?
There is relatively little medical and scientific research regarding CBD. This is due in large part to legal and research limitations. Some studies indicate promising benefits, but the research is young, and it is still too early to come to any definitive conclusions about the perceived health benefits of CBD.
Have you ever felt the famed “runner’s high”? You can thank your endocannabinoid system for that. After a period of strenuous exercise, the body begins to produce an endocannabinoid called anandamide. Anandamide activates both CB1 and CB2 receptors. When the anandamide activates the CB1 receptors, it produces an almost euphoric feeling while the activation of the CB2 receptors soothes discomfort in the muscles and joints.
Because doTERRA Copaiba essential oil has approximately 55 percent BCP content, the amount of oil needed to produce noticeable results is incredibly small—only a couple of drops. doTERRA Copaiba oil is actually a blend of oils that come from four species of the copaifera tree: Copaifera reticulata, Copaifera officinalis, Copaifera coriacea, and Copaifera langsdorffii. This blend of multiple copaifera species contributes to a more potent and effective version of the essential oil.
CB1 receptors are found mainly in the brain and throughout the central nervous system 2 . They are primarily associated with pleasure and reward pathways.