11. Russo, E. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344-1364.
CBD is legal – at the federal level (kind of), and in most but not all states (more on this later).
4. Philpott HT, et al. Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain. 2017 Dec; 158(12): 2442–2451.
How long does it take for CBD oil to work for joint pain?
5. Yamaoka G, et al. Different analgesic effects of adenosine between postoperative and neuropathic pain. J Orthop Sci. 2013;18(1):130-136.
CBD is thought to be helpful in easing the symptoms of the following conditions
When we talk about CBD, we are typically talking about CBD products, such as topical creams and ingestible oils that are created by extracting the CBD compound from the marijuana plant. Although, some CBD products do contain small amounts of THC – which we will get to.
A CBD isolate refers to a product that is composed of the CBD compound only and is extracted from the marijuana plant. CBD isolates can be extracted from both hemp and non-hemp species of marijuana. Remember, for it to be federally legal, it must come from the hemp species. In states where medicinal marijuana is legal, you can find CBD isolates in a marijuana dispensary. Additionally, certain CBD isolates are synthetic forms, such as those used in the pharmaceuticals Marinol and Syndros – both FDA approved to relieve chemotherapy-induced nausea and to improve appetite in people with AIDS. 3
In this report, researchers reviewed 16 previously published studies testing the use of various cannabis-based medicines in the treatment of chronic neuropathic pain and found some evidence that cannabis-based medicines may help with pain relief and reduce pain intensity, sleep difficulties, and psychological distress.
When taken orally, CBD has poor bioavailability. Topical CBD application to localized areas of pain appears to provide more consistent levels of CBD with less systemic involvement.
In studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported. These include anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.
Chronic Neuropathic Pain
In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa.
For many people experiencing chronic pain, cannabidiol (CBD) oil is steadily gaining popularity as a natural approach to pain relief. A compound found in the marijuana plant, cannabidiol is sometimes touted as an alternative to pain medication in the treatment of common conditions like arthritis and back pain.
The use of cannabis for pain relief dates back to ancient China. It’s thought that CBD oil might help ease chronic pain in part by reducing inflammation. In addition, CBD oil is said to promote sounder sleep and, in turn, treat sleep disruption commonly experienced by people with chronic pain.
Over-the-counter (OTC) and prescription pain medications are often recommended in the treatment of chronic pain, but many people seek out alternative forms of relief, such as herbs, nutritional supplements, and products like CBD oil.
For this study, the team focused on 878 people with fibromyalgia who said they used CBD to get more insight into how they used CBD products.
Previous research shows that some people substitute medical cannabis (often with high concentrations of THC) for opioids and other pain medications, reporting that cannabis provides better pain relief and fewer side effects. However, there is far less data on CBD use.
“I was not expecting that level of substitution,” said Boehnke, noting that the rate is quite similar to the substitution rate reported in the medical cannabis literature. People who said they used CBD products that also contained THC had higher odds of substitution and reported greater symptom relief.
Boehnke and his team surveyed people with fibromyalgia about their use of CBD for treatment of chronic pain.
Fibromyalgia is one of many chronic pain conditions that remains stubbornly difficult to treat.
The cannabis-derived substance provides fewer side effects, with less potential for abuse.
The cannabis industry has exploded, aided by the legalization of medical and recreational marijuana in states around the United States and the removal of hemp-derived CBD from Schedule 1 status—reserved for drugs with no currently accepted medical use and a high potential for abuse—at the federal level.