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cbd oil liver

However, one of the caveats of this study was that it tested the maximum recommended daily dosage for humans. While all mammals share the same endocannabinoid system, mice and humans are different physiologically. The size of the liver is just one of the many variables that should be taken into consideration when evaluating the safety of CBD in human subjects.

Now it’s time to ask a different question: what positive effects does CBD have on the liver?

Effects of CBD On the Liver

In addition, repeated doses of a smaller amount of CBD (50 mg) also showed signs of liver damage and swelling.

As the use of CBD is booming across the United States, people have become more aware of its health benefits as well as potential risks associated with the consumption of CBD products.

Human studies that have examined the safety of different doses of CBD have found no negative effects at the recommended maximum daily dosage of 20 mg/kg. This dosage was taken from the trial of Epidiolex, a CBD-based pharmaceutical for treatment-resistant seizures. To put that in context, an individual weighing 150 pounds would need to take over 1,300 mg of CBD per day, which is way above what most people take (10–80 mg daily).

The first step in this study is to determine the correct dose for each patient. Patients will be given the maximum dose of cannabis oil that can be given without causing side-effects. Blood tests will be carried out and images made of the livers of those taking part after three, six and nine months to see whether the liver tumours are responding. The blood will be tested for the presence of tumour markers and to check the liver function of the participants.

The cannabis oil being used is produced by the Transvaal Apotheek, a specialist pharmacy with the certificates needed to produce drugs for research purposes. The oil is produced according to a fixed recipe with precise amounts of THC and CBD, two of the important substances contained in cannabis.

The University Medical Centre Groningen (UMCG), Netherlands, is to study the effect of cannabis oil on liver cancer patients who have exhausted all other treatment options. The aim of the study is to see whether cannabis oil acts as an anti-cancer agent that will shrink the liver tumours.

Research design

The study was started after two separate reports that patients with advanced liver cancer had seen their tumours shrink after using cannabis oil. Now, two and five years after their diagnoses, the tumours have completely dissapeared and the patients are cured. Although laboratory research shows that cannabis can curb the growth of liver cancer cells, a possible anti-cancer effect of cannabis oil in patients cannot be explained as no scientific research has been carried out.

This article is based on an UMCG press release.

The pharmacy only uses medicinal cannabis produced by Bedrocan. The Ministry of Health, Welfare and Sport has commissioned Bedrocan to standardize and grow the plant pharmaceutically in order to guarantee a consistent composition of the cannabis oil.

This study is being carried out with the help of patients with advanced liver cancer, for whom best supportive care is the only remaining option. As cannabis oil is broken down by the liver, all participants must have a good liver function. Patients with severe liver cirrhosis (liver damage caused by the formation of scar tissue) will not be considered for the study unless the cirrhosis is not affecting their liver function. Patients willing to join the study can be referred to the UMCG by their specialist. A total of 20 patients can take part. The study will last approximately three years.

However, initial findings suggest that side effects are minimal and it is only if you take a comparably huge dose of CBD Oil that your liver could be affected.

Following a single study on mice last year, there have been concerns about CBD oil possibly being damaging to your liver if it is used in high quantities.

Any new supplements you are considering adding to your diet should be looked at carefully. Do they fit with your lifestyle? Will they interact with any prescription medications you’re on?

Can CBD Cause Liver Failure?

Signs that your liver isn’t working properly include yellow skin or eyes, known as jaundice, abdominal pain or bloating and swelling of the legs and feet.

Taken by itself, there is no negative impact on core functions such as digestion, heart rate or glucose levels, even with higher doses of CBD oil (up to 1,500mg per day).

Taking the correct, recommended dose of good quality CBD pil as part of a general wellness routine is unlikely to cause any side effects, including liver damage. Any side effects reported in humans up to now are very rare – and very mild if they do occur.

It is the same with any drug or supplement. If you take more than the recommended dose there are always possible consequences, whether it be an excessive dose of grapefruit extract or ibuprofen. Studies have shown that using more than the recommended dose of ibuprofen, for example, can cause stomach ulcers and other gastrointestinal problems as well as greater risk of cardiovascular concerns.