CB1 receptors are mostly found in the brain and central nervous system, but there are some concentrations of these receptors in reproductive organs, lungs, liver, retina, and urinary tracts.
As for the results, I was satisfied when it came to pain and irritation. I also noticed that my stomach was calmer than before taking this oil. However, there’s a reason why I’ve placed CBDistillery at the very bottom of this compilation. Unlike competitor brands, this one doesn’t use organic hemp plants.
Full-spectrum CBD oil contains all phytonutrients naturally found in hemp, including terpenes, flavonoids, and trace cannabinoids. These compounds work together to amplify the health benefits of each cannabinoid, producing the “entourage effect.”
How Could CBD Oil Help With Neuropathy?
CBD can inhibit inflammatory and neuropathic pain caused by autoimmune diseases. In a 2016 animal study published in the European Journal of Pain, topical application of CBD helped reduce pain and inflammation triggered by arthritis.
The above review examined hundreds of studies on using cannabinoid-based medicines on neuropathic pain in adults. While not all of them turned out positive, there was significant evidence that cannabinoids could reduce nerve pain and other symptoms of this condition.
Everybody will react to CBD differently because we’re not made the same. You need to ask yourself a few questions.
If you experience nerve pain — whether regularly or from time to time (like me) — this potency will probably be your go-to choice. It has a deeply relaxing effect and can reduce inflammation for quite a long time after ingestion. I take it under the tongue, wishing the extract around my mouth to increase the surface area for absorption and minimize the amount of oil that passes through the gut.
Medterra is a growing company that is driven by agricultural quality standards to deliver high quality products and customer satisfaction.
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Spruce CBD is newer to the CBD industry but they broke onto the scene with some of the most potent products currently available. Their mission is to provide high-quality alternatives to pharmaceutical medicine that provides maximum relief.
CBD provides the health benefits of cannabis without the psychoactive effects, or “high”, associated with THC. While some CBD products may contain THC, products without THC are also available. [Bergamaschi 2011] 
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Neuropathy is among the symptoms that lupus sufferers commonly experience. LupusCorner, a website for patients with the condition run by health-care technology developer Progentec Diagnostics, conducted an online survey in 2016 asking readers about cannabis use. Of the 781 respondents with lupus who reported using cannabis for various reasons, including as a treatment for their autoimmune disorder, 36% said they were using cannabis, either through smoking, topical application, or another method such as ingesting edibles.
A 2012 literature review published in the Journal of Experimental Medicine examined at least one way that cannabinoids suppress inflammatory and neuropathic pain, by targeting alpha-3 glycine receptors. Citing the difficulty of treating neuropathic pain, the researchers also noted that CBD might be able to address the persistent discomfort associated with a range of diseases.
CBD may relieve neuropathic pain by activating the brain’s serotonin receptors. Photo by: Gina Coleman/Weedmaps
“Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.”
Many medical experts are tentatively on board with cannabis as a viable treatment option for chronic pain and many see potential in CBD, though further research is needed. Dr. Bonni Goldstein, the medical director of Canna-Centers Wellness & Education in California and medical adviser to Weedmaps, stated in her article, “The Neuroprotective Properties of Cannabinoids,” that “if a person suffering from pain uses cannabis medicine, pain is often minimized or eliminated.”