THC is a potent anti-inflammatory and pain killer as well, but on top of that, it produces a set of psychoactive effects known as a “high.” This “high” feeling usually elevates the user’s mood provided that they take it in moderate doses. However, high doses of CBD are known for their backfire effect, which can lead to more anxiety and paranoid thinking patterns.
These recommendations are based on the alleged anti-inflammatory benefits of specific herbs upon consumption.
If you’re flirting with the idea of taking CBD oil for ulcerative colitis, this article will give you a detailed look into the scientific research on this subject on top of sharing some handy tips for using CBD.
CBD vs THC: Which Is Better for IBD Symptoms
If you decide to try CBD for ulcerative colitis or Crohn’s disease, it’s important to choose a form that will be the most beneficial. CBD is available in oil drops, capsules, edibles, vapes, and topicals; each of these products has different bioavailability, addresses different problems, and suits different types of users.
Ulcerative colitis symptoms include:
As mentioned, CBD has remarkable anti-inflammatory and painkilling effects. On top of that, it can modulate the inflammatory response of the immune system by improving communication between its cells. Numerous studies have mentioned these qualities in relation to a wide range of health conditions, including IBD and its symptoms.
Although there have not yet been clinical trials that would investigate the use of CBD oil for ulcerative colitis, preliminary research carried out for the last decade shows promising results.
The effects of cannabis and cannabis oil on ulcerative colitis are uncertain, thus no firm conclusions regarding the effectiveness and safety of cannabis or cannabis oil in adults with active ulcerative colitis can be drawn. There is no evidence for cannabis or cannabis oil use for maintenance of remission in ulcerative colitis. Further studies with a larger number of participants are required to assess the effects of cannabis in people with active and inactive ulcerative colitis. Different doses of cannabis and routes of administration should be investigated. Lastly, follow-up is needed to assess the long term safety outcomes of frequent cannabis use.
We searched MEDLINE, Embase, WHO ICTRP, AMED, PsychINFO, the Cochrane IBD Group Specialized Register, CENTRAL, ClinicalTrials.Gov and the European Clinical Trials Register from inception to 2 January 2018. Conference abstracts and references were searched to identify additional studies.
What are cannabis and cannabinoids?
Cannabis and cannabinoids are often promoted as treatment for many illnesses and are widely used among patients with ulcerative colitis (UC). Few studies have evaluated the use of these agents in UC. Further, cannabis has potential for adverse events and the long-term consequences of cannabis and cannabinoid use in UC are unknown.
What did the researchers investigate?
Two studies including 92 adult participants with ulcerative colitis were included. Both studies assessed cannabis therapy in participants who had active ulcerative colitis. No studies that assessed cannabis therapy in participants with ulcerative colitis in remission were identified. One study (60 participants) compared 10 weeks of treatment with capsules containing cannabis oil with up to 4.7% D9-tetrahydrocannabinol (THC) to placebo in participants with mild to moderately active ulcerative colitis. The starting dose of cannabidiol was 50 mg twice daily which was increased, if tolerated, to a target of 250 mg twice daily. The other study (32 participants) compared 8 weeks of treatment with two cannabis cigarettes per day containing 0.5 g of cannabis, corresponding to 11.5 mg THC to placebo cigarettes in participants with ulcerative colitis who did not respond to conventional medical treatment.
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Updated on December 4, 2020 – Written by Kathy Shattler, MS, RDN
Medically reviewed by Kimberly Langdon, MD
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