Posted on

cbd oil for histamine

There’s always a downside though and that’s the allergenicity of marijuana. It’s a pollinating plant so please exercise caution and as always, always consult with your doctor, because I’m certainly not one!

Here’s an interesting one for you. Our brain has receptors for cannabinoids, which are found in marijuana and other non-psychoactive plants. A study published in the Journal of Allergy and Immunology finds that stimulating the brain’s cannabinoid 1 receptor (CB1) may be useful in managing allergies and skin diseases (meaning rashes and eczema). CB1 receptor stimulation and inhibition were directly linked to mast cell activity.

In the meantime I’d love to hear your experiences.

This post has been a long time coming. Not a day goes by that I don’t receive an email from someone telling me that marijuana has improved their mast cell/histamine intolerance symptoms. My own experiences with it had not been so favourable and I allowed it to colour my view on the topic despite all the wonderful (some anecdotal) news on it helping treat autoimmune disorders and cancer. Being in Los Angeles for the last two months where I’m surrounded by people working in the medical marijuana industry has prompted me to finally buckle down and see what’s the deal with all this.

To be clear, I’m not interested in using it for anything other than its anti-inflammatory properties. Therefore for the purposes of this article I’m covering studies using cannabidiol (CBD), a non-psychoactive compound derived from marijuana. Tetrahydrocannabidiol (THC) is the stuff that gets you high.

Dudášová, A., S.d. Keir, M.e. Parsons, A. Molleman, and C.p. Page. “The Effects of Cannabidiol on the Antigen-induced Contraction of Airways Smooth Muscle in the Guinea-pig.” Pulmonary Pharmacology & Therapeutics 26.3 (2013): 373-79. Web.

You’ll find recipes full of foods with antihistamine and anti-inflammatory properties my books Anti-Recipes and The Anti-Cookbook

The endocannabinoid system (ECS ) is involved in numerous pathologies within the body. Receptors in the ECS, also known as endocannabinoid receptors, are located in the pain and inflammatory processing areas of the brain. Phytocannabinoids, for instance, modulate inflammatory responses within the body by regulating the production of cytokines (aka phytocannabinoids may help reduce inflammation).

A 2005 anti-inflammatory and cannabis study suggested that cannabis can help prevent an increased histamine response. Researchers found that exposure to tetrahydrocannabinol, THC, the psychoactive component of cannabis, could reduce mast cell activation. By reducing mast cell activation, there is less release of histamine to trigger allergic reactions.


Decongestants may help relieve congestion caused by allergies. There are often prescribed as antihistamines. You can find decongestants in multiple forms: eye drops, nasal sprays, liquids, or pill forms. Common OTC decongestants are:

While conventional allergy medications are commonly recommended or prescribed, all-natural, holistic alternatives aren’t quite there yet. Over the last 20 years, cannabinoid research and its effects on allergic reactions are making headway. CBD has been suggested to impair antibody responses and decrease allergy symptoms.

Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, sleep disorders, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

Learn all about CBD and histamines here:

There’s lots of research on CBD’s calming effects for histamine but one specific example:

Anecdotally, here’s my response.

Looking at all the research, we’re starting to think the “side effects” people have with CBD (usually minor) are due to the full spectrum plant material!

Most importantly, the type of CBD you take can make ALL the difference.

Since the number of people with allergic issues is growing each year and well over 50%, it reasons that CBD isolate should be the default option for CBD.

The type of CBD you take can do more harm than good.

CBD has even been shown to help repair the gut barrier which is critical to immune response through the body: