Unlike some other components of the cannabis sativa plant – CBD is not psychoactive. Meaning it will exhibit its benefits without the feeling of becoming high.
To back this up, a study published in the British Journal of Pharmacology found that CBD induced fast and sustained antidepressant-like effects in animal models comparable to those of imipramine. Imipramine is a tricyclic antidepressant (TCA) used mainly for the treatment of depression.
What is CBD
CBD also appears to work faster than most antidepressant medications, including sertraline, which in most cases takes weeks to start performing.
So, to conclude on this point, replacing sertraline with CBD is not recommended, and as always, we would recommend that you consult with your doctor if you plan to do so.
Aside from its benefits, drugs like sertraline do have their side effects. Still, sertraline helps improve your overall mood, supports quality of sleep, and boosts appetite and energy levels to restore your interest in daily living. It also reduces fear, anxiety, and other unwanted thoughts.
Cannabidiol, also known as CBD, is a major component of cannabis (i.e. marijuana).
There are many studies that postulate that while CBD does inhibit metabolizing enzymes, it is not significant and the blood concentrations needed to affect these metabolizing enzymes in humans far exceeds what is possible with usual dosing.
However, additional data on CBD drug interactions indicate the risk of an interaction between CBD and Zoloft specifically is low.
In addition, since Zoloft is metabolized in the body by a number of enzymes, it is thought that it would be difficult for a single agent to cause a clinically significant interaction. In the words of one study:
While THC (delta-9-tetrahydrocannabinol) is likely more well-known due to its psychoactive and euphoric effects, CBD makes up almost 40% of cannabis extracts and has a wide range of potential benefits when used medicinally, although more studies are certainly needed to better understand the compound.