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cbd oil and lymphoma

It is during deep sleep that the body and brain undergo regenerative [10] and restorative processes. Cannabis encourages deeper sleeps for longer periods. Getting good sleep is crucial to maintaining a healthy lymphatic and immune system. Decreased sleep is linked [11] to poor immune function, which must be avoided at all costs by lymphoma patients.

Hodgkin’s lymphoma turns off the body’s seek and destroy system. Cells that would have been targeted and flushed are now able to multiply as they please. This manifests in the body as swollen lymph nodes, usually in the chest and armpits.

The compromised immune system also makes the patient vulnerable to infection, bacterial diseases, and viruses. When your body gets a cold or the flu, the symptoms you experience are your body’s battle with the pathogen flowing in your blood. All thanks to your immune system.

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Hodgkin’s lymphoma or Hodgkin’s disease is a disorder of the lymphatic system. There are lymph nodes all over the body, including in the brain, bone marrow, and spleen. You can feel them as little lumps in your groin, armpits, and along the underside of the jaw. If you can feel them in your bone marrow or brain, you are pressing too hard.

Rapidly absorbed CBD also has a positive [9] effect on mood. While many pharmaceutical antidepressants may take several weeks to balance out in the body, studies performed on rodents suggest a positive effect on mood with just a single dose of CBD.

Cannabis can be a powerful therapeutic tool. It has helped many people with a number of conditions. Can it aid people with Hodgkin’s lymphoma and give them a better quality of life?

In general, medical marijuana patients prefer the magical green herb to other pain control medications. Prescription pain medication can have its own debilitating side effects like intoxication and addiction. A significant amount of distress from pain is caused by anxiety about the pain. The classic high experienced when using cannabis can reduce anxiety and make the pain less psychologically agonising.

Together, these findings provide a novel mechanism underlying the anti-invasive action of CBD on human lung cancer cells and imply its use as a therapeutic option for the treatment of highly invasive cancers.

Chemical structures of Δ 9 -tetrahydrocannabinol (Δ 9 -THC), cannabidiol (CBD), anandamide (AEA) and WIN55212-2

Together, the results suggest that CBD, acting through CB2 receptors and ROS production, may represent a novel and highly selective treatment for leukaemia. Moreover, previous evidence indicated that human leukaemias and lymphomas expressed significantly higher levels of CB2 receptors compared with other tumour cell lines, suggesting that tumours of immune origin may be highly sensitive to the CB2-mediated effects of CBD [46].

CBD and colon cancer

Further biochemical analysis of glioma tumour tissues excised from nude mice treated in vivo with CBD indicated a significant decrease of activity and content of 5-LOX, as well as a marked stimulation of FAAH and a decrease of AEA content [42].

Surprisingly, so far no study has investigated the effect of CBD on angiogenesis. Our data currently awaiting publication [58] demonstrated that CBD potently inhibited HUVE cells proliferation, migration and invasion through the induction of endothelial cell cytostasis without triggering apoptosis. Interestingly, CBD also affected endothelial cell differentiation into tubular capillaries as well as the outgrowth of capillary-like structures from HUVEC spheroids in vitro. In addition, the anti-angiogenic properties of CBD were demonstrated also in vivo, using a matrigel sponge model. These effects were associated with down-modulation of several molecules associated with angiogenesis, including MMP2, MMP9, uPA, endothelin-1, PDGF-AA and CXCL16.

Angiogenesis consists of the formation of new blood vessels from pre-existing ones and represents another promising therapeutic target for cancer therapy. Collectively, cannabinoids have been demonstrated to act as anti-angiogenic factors by disposing tumour cells to decrease the production of pro-angiogenic factors and/or by direct modulation of endothelial cells [27].

Additionally,in vivo studies in thymic aplastic nude mice revealed a significant inhibition of A549 lung metastases following CBD treatment [51] and a significant downregulation of PAI-1 protein was demonstrated in A549 xenografts of CBD-treated rats [52].