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cbd oil and heart disease

Scott Lundgren, DO, Nebraska Medicine.

JCI Insight: “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.”

CBD oil must be studied in randomized clinical trials on people, not animals, before it can be considered safe or effective for heart failure, Lundgren says. Until that happens, he advises against buying or using CBD. “There is some evidence that CBD can cause liver injury as well as lead to male infertility issues. When consumed with alcohol, individuals may experience increased drowsiness, which can lead to household injuries.”

CBD May Have Health Risks

CBD oil contains cannabidiol, an herbal liquid supplement made from the cannabis plant. It doesn’t have the same effect on the brain as THC, another compound found in cannabis that gives you a “high” when smoked or eaten, says Larry Allen, MD, associate division head for clinical affairs in cardiology at University of Colorado Anschutz Medical Campus.

“Does it stimulate your appetite? Yes. Do people gain weight if they take it? Possibly true. Patients with severe heart failure do have cachexia,” or severe weight loss and muscle wasting, he says. “One could argue that people with nausea, lack of appetite, or who are losing weight could think CBD would help them. People with heart failure have a fair amount of discomfort, including edema [swelling] and somatic or pain-related issues, so you could think CBD has a role.”

In 2018, the FDA approved the first oral, purified CBD drug, Epidiolex, to treat seizures in two rare forms of epilepsy. Two synthetic versions of cannabidiol were later approved: dronabinol (Marinol, Syndros) for treatment of nausea during cancer chemotherapy and nabilone (Cesamet) to treat weight loss associated with AIDS.

ClinicalTrials.gov: “Cannabidiol in Patients With Heart Failure in AHA/ACC Stages A-C (CAPITAL-AC).” NCT03634189.

Obesity is one of the leading causes of congestive heart failure, which is one reason why it is important to maintain a healthy weight for optimal heart health. There is some evidence to suggest that CBD may help maintain a healthy weight.

If you’re just starting off with CBD, try a small dose first. Watch for any side effects. If you wish, you can slowly increase your dosage (no more than 5 to 10 mg increase at a time) until you find the dosage that is right for you.

Exercise caution and speak with your doctor before using CBD for heart failure.

Are There Any Side Effects?

CBD is perhaps best known for its anti-inflammatory properties. Research suggests that inflammation may be at the root of many chronic illnesses. Heart disease is associated with inflammation. Inflamed blood vessels make it harder for the heart to pump blood throughout the body.

Heart failure has a number of causes, including genetics, other medical conditions (e.g., anemia, diabetes, sleep apnea), and lifestyle (e.g., smoking, obesity).

Tinnakorn Jorruang / Getty Images

Heart health is one of the areas being explored to determine the therapeutic health benefits of cannabidiol (CBD). Nearly 655,000 Americans die from heart disease every year, accounting for one in every four deaths.