There’s no denying that CBD, aka cannabidiol, has been the reigning trend of the last few years, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic, and safe way to manage a variety of health issues, you may be wondering if you can take CBD and antidepressants together. And while CBD is touted as an all-natural supplement with some evidence that it can be good for your health, it’s possible that your CBD latte can still impact the efficacy of different medications — including antidepressants.
The reason for this is that CBD inhibits two main enzyme systems, Grinspoon explains. Enzymes are proteins that speed up chemical reactions in the body, and play an important role in functions like digestion and respiration. They also help you metabolize antidepressants. “One system is the same one that grapefruit inhibits — the technical name is the CYP34A enzyme system. So, just like grapefruit juice, CBD can cause your body to have higher doses of benzodiazepines [anti-anxiety medications], or certain antipsychotic medications,” Grinspon explains.
“Generally speaking, you can safely use CBD supplements when you’re taking antidepressants. However, there are a couple concerns,” Dr. Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction, tells Bustle. “The first concern is that CBD isn’t regulated by the FDA. You have to be careful that the CBD you’re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because they’ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.” (THC is the cannabis compound that, unlike CBD, can get you high.)
Despite this, Grinspoon explains that this is typically not a large cause of concern for a majority of people on antidepressants or other psychiatric medications. “Certainly, if someone is on a very delicately balanced medical regiment, CBD could knock that out of whack because of the two different enzyme systems it inhibits. In terms of actual clinical practice, I haven’t heard any stories of people having clinical decompensation because of adding CBD to their regime,” he says.
When it comes down to it, Grinspoon says that the potential interactions should be regarded as more “hypothetical than real,” and that the side effect profile of CBD is “very minimal.” Of course, it’s always good to have a conversation with your physician about potential interactions, and to disclose any prescribed or over-the-counter medications and supplements you are taking. At the end of the day, using CBD supplements while on antidepressants is an individual choice, but it’s important to go in informed.
American Shaman does not believe in hard sell tactics. Gleichenhaus candidly admits that senior citizens have enough to deal with, both health-wise, and to avoid being taken in by pushy salespeople and scam artists.
CBD American Shaman is headquartered in Kansas City, Missouri, and has over 150 stores in the Midwest. Although CBD is not legal in all 50 states, their CBD is sourced from industrial hemp grown in Kentucky, which is legal under the farm bill.
While humans are trying blueberry and strawberry flavors, cats are consuming fish flavor, and there is a meat flavor for dogs.
Gleichenhaus’ store even has a section for senior pets. “We see pets with separation anxiety, or they have trouble navigating stairs like they used to. Some pets have thunder anxiety during the rainy season,” he says.
During Gleichenhaus’ grand opening, he was pleasantly surprised to hear from a number of his new customers, that they ordered his products from the Internet, and were excited that the brand had finally come to Delray.
It’s important to look for quality CBD oil and also understand what type of extraction you want to consume. There are three common types of CBD extractions that are used in CBD products: full spectrum, isolate, and broad spectrum CBD. Each type of CBD offers different benefits and can make a big difference when selecting the type to treat specific health uses.
Brain scans of those who suffer from major depression and anxiety have shown that the hippocampus in the brain, critical for a variety of functions including emotion and memory, is smaller than those who do not have these mental conditions.
Enzymes found in CBD are proteins that can speed up chemical reactions in the body. Enzymes help with digestion and other functions, such as respiration. These enzymes can therefore cause your body to potentially have higher doses of anti-anxiety medications or certain antipsychotic medications.
Is it safe to take CBD oil and SSRI antidepressants?
Selective Serotonin Reuptake Inhibitors (SSRIs), better known as antidepressant medications, work to increase the activity of certain neurotransmitters in the brain. Serotonin, norepinephrine, and dopamine are chemicals in the brain that impact mood and feelings of well-being. SSRIs help to increase the activity of these specific neurotransmitters, thereby decreasing symptoms of depression and anxiety.
Broad Spectrum CBD is very similar to full spectrum with one key difference: all trace amounts of THC have been removed completely. Although the hemp plant naturally contains very little amounts of THC (less than 0.3% by weight) broad spectrum CBD is devoid of virtually all THC.
While more scientific research is needed to see how CBD oil and SSRIs can work together, medical experts say it is safe for CBD oil and SSRIs to be taken together.
If you’re looking to incorporate CBD oil with antidepressant use or want to try CBD oil on its own to help deal with depression; a key point of note is to start with a low dose and gradually increase dosage as needed.