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cbd medical condition

Some people with CBD also have dementia, although this doesn’t always occur, symptoms may include:

The condition tends to develop gradually, which means it can be mistaken for another condition at first – such as Parkinson’s disease, dementia or a stroke.

As CBD progresses, it may eventually start to cause problems in your other limbs.

Mid-stage symptoms

Other problems people with advanced CBD can experience include:

The symptoms typically become more severe over several years, although the speed at which they worsen varies.

CBD typically affects one of the limbs at first. This is usually a hand or arm, but sometimes a leg.

As CBD reaches an advanced stage, muscle stiffness will continue to get worse. People with the condition may lose the ability to move 1 or more limbs. Some people are unable to walk and need a wheelchair or assistance to transfer (such as help getting into and out of bed).

Physical therapy may be beneficial in maintaining the mobility and range of motion of stiffened, rigid joints and prevent the development of contractures. Occupational therapy is beneficial in assessing the safety of an affected individual's home and in determining what adaptive medical equipment may increase a person's independence. Speech therapy may be beneficial in treating individuals where speech and language abnormalities associated with corticobasal degeneration. Affected individuals may need devices such as a cane or walker to assist in walking.

Dalvi AI, Bloomfield AS. Parkinson-Plus Syndromes. Emedicine Journal, February 7, 2012. Available at: Accessed on: 09/01/2012.

Pittman AM, Fung HC, de Silva R. Untangling the tau gene association with neurodegenerative disorders. Hum Mol Genet. 2006;15:R188-195.


Parkinson’s disease is a neurodegenerative disease associated with an abnormal protein deposited in cells called alpha-synuclein. However, if brain structures affected in Parkinson’s disease are damaged, parkinsonian symptoms not due to Parkinson’s disease may also occur as a result of head trauma, inflammation of the brain (encephalitis), obstructions (infarcts), or tumors deep within the cerebral hemispheres (cerebrum) and base of the brain (i.e., basal ganglia), or exposure to certain drugs and toxins. Parkinsonian symptoms can include involuntary, resting tremor, muscular stiffness or lack of flexibility (rigidity), slowness of movement (bradykinesia) and difficulty controlling voluntary movements. (For more information on this disorder, choose “Parkinson’s” as your search term in the Rare Disease Database.)

Because signs and symptoms associated with corticobasal degeneration are frequently caused by other neurodegenerative disorders, researchers use the term “corticobasal syndrome” to indicate the clinical diagnosis based on signs and symptoms. The term “corticobasal degeneration” refers to those meeting the neuropathological criteria for the disorder at autopsy. This is an important distinction because clinicopathological series indicate that about less than half of patients diagnosed with corticobasal syndrome during life actually has corticobasal degeneration at autopsy.

For many years, corticobasal degeneration was seen as a neurological condition primarily associated with movement disorders. In recent years, researchers have noted that cognitive and behavioral abnormalities occur more frequently than initially believed. In some cases, the signs and symptoms of dementia may even precede the development of motor symptoms. Initial cognitive symptoms include a nonfluent, progressive aphasia and impairments in executive function. Individuals with corticobasal degeneration can develop a more global loss of intellectual abilities (dementia), usually later in the course of the disease. Affected individuals may also exhibit memory loss, impulsiveness, disinhibition, apathy, irritability, reduced attention span and obsessive-compulsive behaviors.

Corticobasal degeneration (CBD) is a rare progressive neurological disorder characterized by cell loss and deterioration of specific areas of the brain. Affected individuals often initially experience motor abnormalities in one limb that eventually spreads to affect all the arms and legs. Such motor abnormalities include muscle rigidity and the inability to perform purposeful or voluntary movements (apraxia). Affected individuals may have sufficient muscle power for manual tasks, but often have difficulty directing their movements appropriately. Although CBD was historically described as a motor disease, it is now recognized that cognitive and behavioral symptoms also herald CBD and not uncommonly predate motor symptoms. Initial symptoms typically appear in people during the sixth decade, and may include poor coordination or difficulty accomplishing goal-directed tasks (e.g., buttoning a shirt). The exact cause of corticobasal degeneration is unknown.