If you’re using CBD oil for the first time, it’s important to start with a low dose and increase the dosage gradually.
Cost per mg CBD:
This is where CBD may be able to help. There’s evidence it can alleviate a wide range of health conditions related to TBI — such as epileptic seizures, anxiety, sleep disorders and inflammation of the brain.
Common Types of Therapy for Traumatic Brain Injury
Advances in neuroscience research have revealed the mechanisms that lead to TBI’s neurological symptoms such as poor motor control, cognitive decline and post-traumatic epilepsy.
The hours and months following TBI are a critical time of ever-changing biochemical events in the brain. Research has discovered that the endocannabinoid system modulates several of the key secondary injury cascades following TBI.
Common Medications for Traumatic Brain Injury:
Causes commonly include:
But although anecdotal evidence suggests that CBD may be safe and effective for professional athletes, it also may show promise for the treatment of TBIs caused by youth sports, falls, car accidents and military combat injuries. And, researchers are investigating CBD as a potential treatment for other conditions that affect the brain, including Alzheimer’s disease, Parkinson’s disease, stroke, and HIV-associated dementia.
When your brain is injured, it releases neurotransmitters and chemicals that cause inflammation, blood vessel injury, chemical imbalances, tissue damage, and cell death. These brain responses are called a “secondary injury cascade” and are responsible for many of the neurological problems associated with TBI.
Traumatic brain injury (TBI) is a condition that occurs when a head injury, such as a bump, blow, or jolt, causes your brain to slam into the inside of your skull, which results in brain damage.
The Benefits of the “Entourage Effect”
In 1998, researchers published the results of a study on rats that demonstrated the neuroprotective benefits of CBD and tetrahydrocannabinol (THC), which are two of the cannabinoids found in cannabis.  Although more research is required to fully understand the neuroprotective effects of CBD, recent studies have shown that CBD activates the cannabinoid receptors in your brain that are part of your body’s natural endocannabinoid system.
Repeated TBIs can cause a buildup of Tau protein, which can lead to a degenerative neurological condition called chronic traumatic encephalopathy (CTE). CTE can have a devastating impact on individuals and their families because it can cause a variety of symptoms that affect memory, emotions, behavior, movement, and mental functioning.
Many professional athletes have spoken out about the benefits of CBD for the treatment of TBI and CTE symptoms, saying that it helped to regulate their mood, improve physical function, and reduce or eliminate their use of prescription painkillers and other medications.
Because full-spectrum CBD contains a variety of phytocannabinoids, it produces an “entourage effect” that engages both the CB1 and CB2 receptors in the brain — as well as other cannabinoid and non-cannabinoid receptors throughout your body — for maximum neuroprotective and overall health benefits.
However, the ability of cannabinoids such as CBD to fine-tune various vital brain circuits in the nervous system has found bright prospects in the treatment of various forms of dementia including Alzheimer’s. In this regard, a study was conducted and the results were published on PubMed. The study comprised a total of 21 cases in which cannabinoids particularly CBD obtained from Cannabis plants were used as a therapeutic measure against Alzheimer’s disease.
One of the most common neurodegenerative disorders of today is Alzheimer’s disease. It is a neurodegenerative disorder that causes gradual cell death in various areas of the brain occurs, thereby leading to a gradual loss of memories and disability to store new memories. It is the most common cause of dementia today all over the world. It’s a very common misconception that dementia almost always occurs due to Alzheimer’s, which is largely a misleading fact. There are many forms of dementia, including AD, Lewy body dementia, carbon monoxide induced dementia, paralytic dementia, memory loss due to traumatic brain injury, and loss of memory due to undersupply of blood to various areas of the brain.
Schizophrenia is a disorder characterized by a patient having a skewed perception of reality. Symptoms are usually psychic and involve frequent delusions accompanied by hallucinations, and disordered behavior that might result in disability. The onset of schizophrenia is upon late adolescence, but the disease also might appear in the people in their early twenties or thirties having no particular symptoms. It might also affect speech and thinking of the subject. People suffering from this disturbing mental disease experience an extremely disturbed lifestyle, that primarily causes major disturbances in the sleep patterns.
CBD to Treat Alzheimer’s and Other Forms of Dementia
The effects of combining CBD oil along with hypothermia treatment to treat HIE appeared to be more promising than simply using CBD or hypothermia therapy to treat the congenital brain damage leading to hypoxic ischemic encephalopathy. Dr. Martinez Orgado, a Spanish associate professor of pediatrics, studied the effects of hypothermia therapy along with injecting CBD to the patients with congenital brain damage. The results of the study were very promising, and the use of CBD along with hypothermia therapy eliminated brain damage almost entirely. The treatment has started in Spain and the United Kingdom, involving babies suffering from brain damage getting hypothermia therapy alone, hypothermia along with CBD or hypothermia along with a placebo.
Parkinsonism is a neurodegenerative disorder characterized by involuntary tremors throughout the body, stiffness, and rigidity. The disease gradually progresses over time like Alzheimer’s, and the symptoms get greater over time. Parkinson’s disease is caused due to degeneration in the areas of the brain that produce dopamine: a neurotransmitter involved in executive functions of the brain such as coordinating the motor control of muscles, as well as lower-level functions including lactation, sexual function, and nausea. The exact cause of cell death in the areas that produce dopamine in the brain is still not understood to the scientists and continues to be the hotspot of Parkinsonism research.
We have explained how CBD helps reduce the inflammation in the nervous tissue through its pathways. The endocannabinoid system is naturally self-protective in the humans so that the system has protective measures in place. The anti-inflammatory effects of CBD are quite well understood. CBD serves to activate the Peroxisome Proliferator-Activated Receptor through a pathway in the central nervous system that is well understood. When this pathway is activated, the neuroprotective abilities of the endocannabinoid system are enhanced, and the neuronal PC12 cells are protected from neurotoxicity and oxidative stress.
The primary mechanism due to which CBD can be used to avert brain damage due to the traumatic brain injury lies in the vast anti-inflammatory properties of the CBD. CBD averts inflammation due to various ways. One of the factors through which CBD can avoid inflammation is the dysfunction of the cytokines (chemical substances in the body which serve to mediate inflammation through promoting it). Endocannabinoids, particularly nonpsychoactive agents such as CBD, affect the cytokine structure and biology of various cell systems. Antiproliferative effects of endocannabinoids on cancer cells have been studied well, and their effect on stopping the inflammation is large. As inflammation particularly spreads vastly after a tissue injury due to contusion or other contact causes, so the rate of inflammation surrounding the brain injury can be particularly dangerous, as it causes necrotic cell death in the tissue on a large scale. This cell death proves fatal to certain brain areas that are hit directly by the injury. So, in the case, if traumatic brain injury, stopping the inflammation gains prime importance, as it reduces the chance of the damage spread. The microglia, or the macrophages that exist in the brain tissue, have a very important role in inflammation. Moreover, there are cells in the brain tissue called astrocytes. The astrocytes serve to nourish the brain tissue under normal circumstances, providing vital nutrients to the neurons thus playing an important role in tissue growth. However, under traumatic brain injury where the brain tissue becomes necrotic, the astrocytes have been found secreting certain cytokines along with other chemicals such as nitric oxide that mediate inflammation.