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A research team that had previously shown CBD’s effect on acne studied other cannabinoids, including CBC, for the same effects. Indeed, CBC was shown to be a powerful inhibitor of acne. As a skin disease, acne is characterized by excess sebum production and sebaceous gland inflammation. It turns out that CBC exhibited powerful anti-inflammatory properties and also suppressed excessive lipid production in the sebaceous glands. CBC also reduced levels of arachidonic acid (AA), which is needed to create the lipogenesis. More research is needed, but CBC might just one day become a very powerful anti-acne treatment.

The purported benefits of CBC have far-reaching implications. Below are a few medical conditions that may be alleviated by cannabichromene.

By now you’re probably familiar with cannabinoids, especially the most common ones, THC and CBD. But you likely haven’t heard of cannabichromene, also known as CBC. Discovered over 50 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It doesn’t get as much attention, but CBC’s benefits are extremely promising.

Brain Cells

In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.

In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis. The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteract many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.

Cannabichromene may be a powerful cancer fighter, and the reason might be its interaction with the body’s natural endocannabinoid, anandamide. CBC also appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream.

While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term known as the entourage effect. This effect of THC and CBD working together is well-known, but whether other cannabinoids have entourage effects is not well understood.

This tag-team phenomenon is known as “the entourage effect,” the research-backed belief that the individual parts of the cannabis sativa plant (leaves, flowers, stalks, and all they contain) amplify each others’ benefits. “When people are finding the true benefits of plant medicine, it’s often not a compound in isolation — it’s all these compounds and botanicals working together in harmony,” Kennedy explains. The founder says Plant People utilizes full-spectrum hemp extract that features all the cannabis compounds that nature provides, including (but not limited to) CBD and CBC.

Dr. Icecreamwala is quick to note that long-term studies on CBD and CBC have not been conducted, so at this point, the full range of risks and rewards isn’t known. “Some people have found cannabinoid-derived skincare products to be anti-inflammatory,” the dermatologist says. “But there could be a risk of irritation or allergic reaction from skincare products that contain this ingredient.” Kennedy adds you should always “consult a doctor before using any type of plant medicine.”

I mean, I’m no doctor… but my official beauty editor opinion? CBC is the most exciting thing to happen to CBD beauty in months, and I personally plan on treating my acne-prone skin to some cannabichromene ASAP.

“Initial research has shown that it has strong topical applications, with anti-inflammatory and anti-acne properties,” Kennedy says (and Dr. Icecreamwala confirms). “This may help with assisting to alleviate various concerns, as it works as an effective antiviral and antibacterial.” To be clear, regular old CBD also has anti-inflammatory properties, but CBC seems to be the stronger contender when it comes to alleviating active acne and keeping future blemishes at bay. Still, it’s doubtful CBC will ever fully replace CBD: The two actually work best when they work together.

Technically, any CBD product made from full-spectrum or whole-plant hemp extract should include small amounts of CBC, but thanks to strategic engineering, Plant People’s Oct. 10 launches — the Nourish Botanical Body Lotion, the Restore Botanical Face Mask, and the Revive Botanical Face Serum — feature some of the highest concentrations of cannabichromene on the market. “Through our approach to plant genetics and unique extraction processes, we are able to focus on bringing specific minor cannabinoids to the forefront,” Kennedy says. “For skincare, we chose to include higher levels of CBC.”

“CBC, which stands for cannabichromene, is a different cannabinoid than CBD,” Dr. Devika Icecreamwala, M.D., a board-certified dermatologist with Icecreamwala Dermatology, tells The Zoe Report. “Like CBD, it is not psychoactive.” (As a refresher: That means it won’t get you high.) Also like CBD, CBC is derived from the cannabis sativa plant — AKA, hemp. “While CBD and CBC come from the same plant, each has its own functional benefits,” Gabe Kennedy, the co-founder of Plant People, tells TZR. “We at Plant People believe in showcasing the opportunity that other compounds bring to the table.” And the opportunity for CBC in skincare is definitely promising.

Just as I was reaching my tolerance threshold for CBD product launches, a new release renewed my interest cannabinoids. Plant People’s latest crop of hemp-derived skincare formulas feature the prerequisite CBD. alongside CBC, a less-hyped but arguably more intriguing cannabis compound, especially for skincare enthusiasts. Research into the CBC cannabinoid’s benefits suggest these three little letters could have a major impact on acne.

Hemp is one type of the cannabis Sativa plant. It is also called industrial hemp and contains a THC level of less than 0.3%. Nevertheless, some of its processed by-products can still offer degrees of euphoria. These include gummies, tinctures, and capsules. CBC is the third most prominent cannabinoid of the cannabis plant, but works best along with its fellow cannabinoids. Most effective CBC products contain more than just CBC itself. Here are a few examples of products from CBC in hemp.

The interaction between CBC and the two pain receptors is a big reason for its numerous potential uses. Below are some of the conditions that CBC may help to manage.

However, when you take products with a combination of THC and CBC, the effects are greater. CBC propels the level of the psychoactive features of THC. It further reacts when mixed with other components of the plant. It will not alter your perception alone because it does not interact with your ECS like CBD and THC. However, it does interact with TRPV1 and TRPA1. These are receptors in your body that effect the brain’s perception of pain. CBC in hemp activates these receptors, resulting in more endocannabinoids in the body.

CBC in Hemp

Cannabichromene has shown trends of blocking pain and consequently inflammation caused by osteoarthritis. When taken independently, it may help patients suffering from this condition by easing excruciating pain. Additionally, when combined with THC, the two cannabinoids can bear even better results. The effects of the combination are exceptional compared to what each of them can do on their own.

Fortunately, you can also get CBC from raw hemp. However, it may be difficult to find depending on where you live and what your local laws are. CBC in isolated form is quite expensive to produce. The extraction process requires using a considerable amount of plants for you to get a reasonable portion. The components aren’t very dense in the plant, thus you need to use more for you to get the required amount. It is this reason why CBC-based products are more costly compared to CBD.

The human brain controls every activity within the body, but needs to be healthy to do so. One of the vital cells that boosts healthy performance is the neural stem progenitor cell. A study has shown taking CBC makes these cells more active, thus propelling the brain’s rate of cell regeneration. These cells further differentiate and become astroglial cells. These are responsible for homeostasis within the brain. The availability of healthy cells helps fight neurologic diseases and pathogens that might affect the brain.

Cancer can affect any part of the human body and usually comes with pain. The typical kind of treatment includes chemotherapy. The effects of this procedure are more pain, nausea, and vomiting. However, cannabichromene is one substance that may aid patients in this outcome, particularly breast cancer. The molecule interacts with endocannabinoids by the name of anandamide. It is a natural cannabinoid made in the body. CBC intake prevents the immediate uptake of this element, allowing it to stay longer within the bloodstream. This is potentially important, because anandamide has the potential to slow down the spread of certain cancer cells.